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2024 Vol.56, Issue 4 Preview Page

Research Article

Tough Bioactive Composite Hydrogel of Gelatin Methacrylate and Bacterial Cellulose Prepared by Combined Freeze-Thaw and Photocrosslinking Processes
Yeji Han1
,
Jinho Hyun12†
1Student, Department of Agricultural, Forestry, and Bioresources, Seoul National University
2Professors, Research Institute of Agriculture and Life Sciences, Seoul National University
†Corresponding author: E-Mail: jhyun@snu.ac.kr (Address: Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, 08826, Republic of Korea)
30 August 2024. pp. 36-44
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Abstract

Despite the excellent structural stability and mechanical properties of bacterial cellulose (BC) hydrogels, BC hydrogels do not have sufficient bioactivity to support the growth and proliferation of tissue cells. Gelatin methacrylate (GelMA) is a good choice to compensate for the bioactivity of BC hydrogel. However, GelMA itself does not provide sufficient mechanical properties for the structure, and it is also difficult to use as an ink for printing at low concentrations. The increase in GelMA concentration can enhance its mechanical properties, but the biocompatibility decreases due to the increased hydrogel density. Here, we prepared a tough and biocompatible composite hydrogel using BC incorporated with GelMA. A freeze-thaw process was introduced in the fabrication of the BC/GelMA composite hydrogel to improve its mechanical properties. The GelMA interpenetrated in the BC structure was freeze-thawed and photo-crosslinked to enhance mechanical properties. Such a process provided double networks within the highly networked structure of BC. Moreover, the order of freeze-thaw and photo-crosslinking created a significantly different reinforcing effect with the BC/GelMA composite hydrogel.

Keywords
3D printing
bacterial cellulose
composite hydrogel
double network
freeze-thaw
gelatin methacrylate
photocrosslinking
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Information
  • Publisher :Korea Technical Association of The Pulp and Paper Industry
  • Publisher(Ko) :한국펄프종이공학회
  • Journal Title :Journal of Korea TAPPI
  • Journal Title(Ko) :펄프종이기술
  • Volume : 56
  • No :4
  • Pages :36-44
  • Received Date : 2024-07-19
  • Revised Date : 2024-08-11
  • Accepted Date : 2024-08-11
  • DOI :https://doi.org/10.7584/JKTAPPI.2024.8.56.4.36
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